Schmolinsky, Julia Charlotte
[Author]
;
Kocher, Thomas
[Degree supervisor];
Nauck, Michael
[Degree supervisor];
Holtfreter, Birte
[Degree supervisor]Universität Greifswald
Auswirkungen von Diabetes mellitus und der metabolischen Kontrolle auf die Karieserfahrung in einer 11-jährigen Longitudinalstudie
We related the common diseases of diabetes mellitus and caries using data from the large population-based SHIP-study to strengthen the hypothesis that diabetes mellitus has an impact on coronal caries. By SHIP-0, -1, and -2, we were able to use data over a total period of 15 years (1997-2012), in which 3731 individuals participated in the baseline study. This is the first longitudinal study with a large sample size to investigate a potential correlation between diabetes mellitus and metabolic control and coronal caries. Coronal caries experience was identified in subjects by DMFS-index and its components using the half-mouth method. A type 2 diabetic was defined via self-reported physician´s diagnosis or intake of glucose-lowering drugs or from an HbA1c level ≥ 6.5% or from a non-fasting blood glucose level of ≥ 11.1 . Subjects were divided into three groups: no diabetes mellitus, well-controlled type 2 diabetes (HbA1c 6.5%-7%), and poorly-controlled type 2 diabetes (HbA1c > 7%). Data were analyzed using covariate-adjusted linear mixed models. The results of our longitudinal population-based 11-year-follow-up-study indicated an HbA1c dependent correlation between diabetes mellitus and coronal caries experience. A poorly-controlled diabetic had higher long-term progression of DMFS (0.761 surfaces per year) than a well-controlled diabetic (0.473 surfaces per year) or a subject without diabetes mellitus (0.480 surfaces per year). A well-controlled diabetic also had the lowest ...