Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik
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Media type:
E-Book;
Thesis
Title:
Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik
Parallel title:
Neurofilament light chains in serum as biomarkers of axonal damage in early MS lesions: a histological-serological correlative study
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL) are considered a biomarker for this damage. We aimed to investigate the relationship between sNfL and the axonal damage in early MS lesions in a special cohort of biopsied patients. sNfL from 106 biopsied patients with 26 follow-up samples were analyzed using single-molecule array (SiMoA) technology. Findings were correlated with clinical parameters and histological findings of acute axonal damage (APP-positive spheroids) and axonal loss in di...