The effects of conventional chemotherapeutics on the activation of type I interferons (IFN-α/β) in hepatic cancer cells in vitro: The significance of endogenous type III interferons (IFN-λ)
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Media type:
E-Book;
Thesis
Title:
The effects of conventional chemotherapeutics on the activation of type I interferons (IFN-α/β) in hepatic cancer cells in vitro: The significance of endogenous type III interferons (IFN-λ)
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
HCC is characterized by limited therapy options, poor response rates to systemic chemotherapy, and high lethality. Preclinical cancer models have revealed the efficacy of genotoxic drugs to rely on the release of type I IFNs by neoplastic cells boosting an antitumor response. This thesis elucidates the capacity of the transplantable hepatoma cancer cell line Hepa 1-6 to activate type I IFNs (IFN-α/β), type III IFNs (IFN-λ) and IFN effectors, and compares the parental Hepa 1-6 cell line to CRISPR/Cas9-engineered Ifnl2/3-deficient isogenic clones in view of preclinical models. Methods: Isogen...