University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Autophagy is a tightly regulated process that eukaryotic cells use as a major survival mechanism to reallocate nutrients to essential processes in adverse conditions such as nutrient or energy deprivation. Autophagy is characterized by the formation of a phagophore, a double membrane organelle that matures into an autophagosome to capture damaged or surplus materials in the cytosol and deliver them to the lysosome for degradation and recycling. Yet, how the autophagosome is generated de novo remains a long-standing question in biology. Research in the last decades has suggested that autopha...