University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Upon myocardial infarction, the natural healing response triggers the fibroblast-to-myofibroblast transition (FMT). Through this process, fibroblasts acquire a myofibroblast phenotype by which they present increased mobility, contractility, and capacity to produce components of the extracellular matrix. These factors contribute to their migration towards the injured site and their effective participation in scar formation. However, the FMT involves a stringent regulation of the mechanics of the cellular cytoskeleton and, therefore, of the dynamics of the actomyosin cortex upon directed cell...