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Fabian, Alexander [Author]; Rühle, Alexander [Author]; Domschikowski, Justus [Author]; Trommer, Maike [Author]; Wegen, Simone [Author]; Becker, Jan-Niklas [Author]; Wurschi, Georg [Author]; Boeke, Simon [Author]; Sonnhoff, Mathias [Author]; Fink, Christoph Andreas [Author]; Käsmann, Lukas [Author]; Schneider, Melanie [Author]; Bockelmann, Elodie [Author]; Treppner, Martin [Author]; Krug, David [Author]; Nicolay, Nils H. [Author]

Financial toxicity in cancer patients undergoing radiotherapy in a universal health care system - a prospective multicenter study of 1075 patients

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  • Media type: E-Article
  • Title: Financial toxicity in cancer patients undergoing radiotherapy in a universal health care system - a prospective multicenter study of 1075 patients
  • Contributor: Fabian, Alexander [Author]; Rühle, Alexander [Author]; Domschikowski, Justus [Author]; Trommer, Maike [Author]; Wegen, Simone [Author]; Becker, Jan-Niklas [Author]; Wurschi, Georg [Author]; Boeke, Simon [Author]; Sonnhoff, Mathias [Author]; Fink, Christoph Andreas [Author]; Käsmann, Lukas [Author]; Schneider, Melanie [Author]; Bockelmann, Elodie [Author]; Treppner, Martin [Author]; Krug, David [Author]; Nicolay, Nils H. [Author]
  • Published: 30 March 2023
  • Published in: Radiotherapy and oncology ; 183(2023) vom: März, Artikel-ID 109604, Seite 1-7
  • Language: English
  • DOI: 10.1016/j.radonc.2023.109604
  • Identifier:
  • Keywords: Financial toxicity ; Oncology ; Patient Satisfaction ; Psychosocial Distress ; Quality of Life ; Supportive Care
  • Origination:
  • Footnote: Online verfügbar 7. März 2023, Artikelversion 30. März 2023
  • Description: Purpose - To establish and confirm prevalence as well as risk factors of financial toxicity in a large national cohort of cancer patients undergoing radiotherapy in a universal health care system. - Methods - We conducted a prospective cross-sectional study offering a patient-reported questionnaire to all eligible cancer patients treated with radiotherapy in 11 centers in Germany during 60 consecutive days. The four-point subjective financial distress question of the EORTC QLQ-C30 was used as a surrogate for financial toxicity. Confirmatory hypothesis testing evaluated the primary study outcomes: overall prevalence of financial toxicity and its association with predefined risk factors. P-values < 0.05 were considered statistically significant. - Results - Of 2341 eligible patients, 1075 (46%) participated. The prevalence of subjective financial distress (=any grade higher than not present) was 41% (438/1075) exceeding the hypothesized range of 26.04-36.31%. Subjective financial distress was felt “A little” by 26% (280/1075), “Quite a bit” by 11% (113/1075) and “Very much” by 4% (45/1075) of the patients. Lower household income, lower global health status/ quality of life, higher direct costs and higher loss of income significantly predicted higher subjective financial distress per ordinal regression and confirmed these risk factors. Higher psychosocial distress and lower patient satisfaction were significantly associated with higher subjective financial distress in an exploratory ordinal regression model. - Conclusion - The overall prevalence of financial toxicity was higher than anticipated, although reported at low or moderate degrees by most affected patients. As we confirmed risk factors associated with financial toxicity, patients at risk should be addressed early for potential support.
  • Access State: Open Access