University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Background: Colorectal cancer is the third most common cancer and the second leading cause of cancer-associated deaths worldwide. Despite early detection screening methods, approximately 25% of patients already have metastases at the time of diagnosis. Recommended treatment is radical surgical resection, including neoadjuvant radiochemotherapy in rectal cancer and adjuvant chemotherapy in stage II and higher stages. In treatment of metastatic carcinomas (stage IV), antibodies and inhibitors such as VEGF and EGFR are widely used. Unfortunately, resistance to established therapies often occur...