Chirurgische Therapie des (lokal) fortgeschrittenen Adenokarzinoms im oberen Rektum – erste Ergebnisse aus der multizentrischen GAST-05-Phase IIb-Studie
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Media type:
E-Book;
Thesis
Title:
Chirurgische Therapie des (lokal) fortgeschrittenen Adenokarzinoms im oberen Rektum – erste Ergebnisse aus der multizentrischen GAST-05-Phase IIb-Studie
Parallel title:
Surgical therapy of (locally) advanced adenocarcinoma in the upper rectum - first results of the multicenter GAST-05 phase IIb study
University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
The prospective, randomized, multicenter GAST-05 phase-IIb study (ISRCTN 35198481), funded by the German research Foundation, was designed to clarify whether partial mesorectal excision (PME, with a distal cancer-free safety margin of 5 cm) is sufficient compared to total mesorectal excision (TME) for patients with adenocarcinomas (cUICC stages ≥ II) in the upper rectum (> 12 cm from anal verge). The surgical results in participants of one GAST-05 study site were assessed, taking various clinicopathological parameters into account. Surgery was performed in 98 (median age: 69 years) patients...