University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Cognitive processes like the formation of memory and learning originate in the correct functioning of synapses. Dendritic spines are highly plastic, specialised actin-rich structures harbouring the postsynaptic site in excitatory glutamatergic synapses. Mechanisms crucial for synaptic physiology, like spine plasticity and neurotransmitter receptor mobilisation depend on synaptic activity and are subjected to actin cytoskeleton dynamics. However, a detailed outline of how the postsynaptic actin architecture changes at the nanoscale in response to distinct synaptic activity states is vastly l...