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Weber, Jan-Niklas [Author]; Minner-Meinen, Rieke [Author]; Behnecke, Maria [Author]; Biedendieck, Rebekka Katrin Johanna [Author]; Hänsch, Veit G. [Author]; Hercher, Thomas Wolfgang [Author]; Hertweck, Christian [Author]; Hout, Lena van den [Author]; Knüppel, Lars [Author]; Sivov, Simon [Author]; Schulze, Jutta [Author]; Mendel, Ralf-Rainer [Author]; Hänsch, Robert [Author]; Kaufholdt, David [Author]

Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis

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  • Media type: E-Book; Special Print
  • Title: Moonlighting Arabidopsis molybdate transporter 2 family and GSH-complex formation facilitate molybdenum homeostasis
  • Contributor: Weber, Jan-Niklas [Author]; Minner-Meinen, Rieke [Author]; Behnecke, Maria [Author]; Biedendieck, Rebekka Katrin Johanna [Author]; Hänsch, Veit G. [Author]; Hercher, Thomas Wolfgang [Author]; Hertweck, Christian [Author]; Hout, Lena van den [Author]; Knüppel, Lars [Author]; Sivov, Simon [Author]; Schulze, Jutta [Author]; Mendel, Ralf-Rainer [Author]; Hänsch, Robert [Author]; Kaufholdt, David [Author]
  • Published: Berlin: Springer, 2023
  • Published in: Communications Biology ; 6, 801 (2023).
  • Extent: 1 Online-Ressource
  • Language: English
  • DOI: 10.1038/s42003-023-05161-x
  • Identifier:
  • Origination:
  • Footnote:
  • Description: Molybdenum (Mo) as essential micronutrient for plants, acts as active component of molybdenum cofactor (Moco). Core metabolic processes like nitrate assimilation or abscisic-acid biosynthesis rely on Moco-dependent enzymes. Although a family of molybdate transport proteins (MOT1) is known to date in Arabidopsis, molybdate homeostasis remained unclear. Here we report a second family of molybdate transporters (MOT2) playing key roles in molybdate distribution and usage. KO phenotype-analyses, cellular and organ-specific localization, and connection to Moco-biosynthesis enzymes via protein-protein interaction suggest involvement in cellular import of molybdate in leaves and reproductive organs. Furthermore, we detected a glutathione-molybdate complex, which reveals how vacuolar storage is maintained. A putative Golgi S-adenosyl-methionine transport function was reported recently for the MOT2-family. Here, we propose a moonlighting function, since clear evidence of molybdate transport was found in a yeast-system. Our characterization of the MOT2-family and the detection of a glutathione-molybdate complex unveil the plant-wide way of molybdate.
  • Access State: Open Access