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Hristomanova Mitkovska, Slavica [Author] ; Uhmann, Anja [Degree supervisor]; Schön, Michael [Degree supervisor]; Dressel, Ralf [Degree supervisor]

In vitro analyses of CD4-protein function in dedifferentiated keratinocyte cell lines

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  • Media type: E-Book; Thesis
  • Title: In vitro analyses of CD4-protein function in dedifferentiated keratinocyte cell lines
  • Contributor: Hristomanova Mitkovska, Slavica [VerfasserIn]; Uhmann, Anja [AkademischeR BetreuerIn]; Schön, Michael [AkademischeR BetreuerIn]; Dressel, Ralf [AkademischeR BetreuerIn]
  • imprint: Göttingen, 2023
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: CD4 ; Epidermal stem cells ; HaCaT ; Cell differentiation/dedifferentiation ; Kerationcytes ; IL-1α ; TNFα ; MHCII ; cAMP ; Keratinocytes ; Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2023
  • Footnote:
  • Description: To study the role of the Hedgehog-Patched (Hh/Ptch) signaling pathway in T-cells, the two-step DMBA/TPA carcinogenesis protocol have been applied to mice with an homozygous Ptch depletion in CD4-expressing cell (Ptch flox/flox CD4Cre+/-). This approach revealed that beside the typically DMBA/TPA-induced papilloma and squamous cell carcinoma also basal cell carcinoma developed in Ptch flox/flox CD4Cre+/- mice. These basal cell carcinoma derive from CD4+ cells of the murine skin that are characterized by their expression of the keratinocyte marker CD49f and the stem cell markers CD34 and Sca1...
  • Access State: Open Access
  • Rights information: Attribution (CC BY)