University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA should get exported into the cytoplasm only after having completed processing successfully, so that a proper translation is ensured. In Saccharomyces cerevisiae, the SR-like guard proteins Gbp2 and Hrb1 control splicing and retain unspliced transcripts in the nucleus while Hrp1 controls the cleavage reaction. The guard Nab2 controls the quality of the 3’-poly(A) ta...