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Neumaier, Michael [Author]; Giesler, Sophie [Author]; Ast, Volker [Author]; Römer, Mathis [Author]; Voß, Timo-Daniel [Author]; Reinz, Eileen [Author]; Costina, Victor [Author]; Schmelz, Martin [Author]; Nürnberg, Elina [Author]; Nittka, Stefanie [Author]; Leppä, Aino-Maija [Author]; Rudolf, Rüdiger [Author]; Trumpp, Andreas [Author]; Fuchs, Tina [Author]

Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies

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  • Media type: E-Article
  • Title: Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies
  • Contributor: Neumaier, Michael [VerfasserIn]; Giesler, Sophie [VerfasserIn]; Ast, Volker [VerfasserIn]; Römer, Mathis [VerfasserIn]; Voß, Timo-Daniel [VerfasserIn]; Reinz, Eileen [VerfasserIn]; Costina, Victor [VerfasserIn]; Schmelz, Martin [VerfasserIn]; Nürnberg, Elina [VerfasserIn]; Nittka, Stefanie [VerfasserIn]; Leppä, Aino-Maija [VerfasserIn]; Rudolf, Rüdiger [VerfasserIn]; Trumpp, Andreas [VerfasserIn]; Fuchs, Tina [VerfasserIn]
  • imprint: Sep 2023
  • Published in: Science advances ; 9(2023), 35, Artikel-ID eadg181, Seite 1-12
  • Language: English
  • DOI: 10.1126/sciadv.adg1812
  • ISSN: 2375-2548
  • Identifier:
  • Origination:
  • Footnote: Online veröffentlicht: 01. September 2023
  • Description: This report demonstrates a novel class of innate immune cells designated “variable immunoreceptor-expressing myeloids” (VIREMs). Using single-cell transcriptomics and genome-wide epigenetic profiling, we establish that VIREMs are myeloid cells unrelated to lymphocytes. We visualize the phenotype of B-VIREMs that are capable of genetically recombining and expressing antibody genes, the exclusive hallmark function of B lymphocytes. These cells, designated B-VIREMs, display monoclonal antibody cell surface signatures and regularly circulate in the blood of healthy individuals. Single-cell data reveal clonal expansion of circulating B-VIREMs as a dynamic response to disease stimuli. Live-cell imaging models suggest that B-VIREMs load their own Fc receptors with endogenous antibodies during vesicle transport to the cell surface. A first cloned B-VIREM-derived antibody (Vab1) specifically binds stomatin, a ubiquitous scaffold protein that is strictly expressed intracellularly, allowing Vab1-bearing macrophages to phagocytose cell debris without requiring prior opsonization. Our results suggest important antigen-specific tissue maintenance functionalities in these innate immune cells.
  • Access State: Open Access