University thesis:
Dissertation, Georg-August-Universität Göttingen, 2022
Footnote:
Description:
Protein quality control by ubiquitination occurs due to the sequential action of three enzyme classes: ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligases (E3). Conventionally, ubiquitin (Ub) attachment by these enzymes occurs via isopeptide bonds, typically to the ε-amino group of lysine residues. Seminal studies from the past have established that non-lysine residues such as serine, threonine and cysteine can also be ubiquitinated via hydroxy- and thio-ester bonds. However, the molecular basis and physiological relevance for such non-canonical ubiquitination remain...