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Xin, Wenqiang [Author] ; Döppner, Prof [Degree supervisor]; Wulf, Prof [Degree supervisor]

Hypoxic microglial extracellular vesicles abrogate poststroke AQP4 depolarization, astrogliosis and meuroinflammation

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  • Media type: E-Book; Thesis
  • Title: Hypoxic microglial extracellular vesicles abrogate poststroke AQP4 depolarization, astrogliosis and meuroinflammation
  • Contributor: Xin, Wenqiang [Author]; Döppner, Prof. [Degree supervisor]; Wulf, Prof. [Degree supervisor]
  • Published: Göttingen, 2023
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: AQP4 ; extracellular vesicles ; microglia ; astrocyte ; stroke ; Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2023
  • Footnote:
  • Description: Reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation occurring and lasting for a long time in the periinfarct region are associated with poststroke brain injury. Our previous work has revealed that extracellular vesicles (EVs) from hypoxic microglia are implicated in protecting against stroke-induced brain damage. Uncertainty persists regarding how poststroke immunological regulation and AQP4 depolarization are affected by hypoxia- induced microglial EVs. Mice were administered with hypoxic microglial EVs via tail vein injections. Cerebral perfusion, edema of the b...
  • Access State: Open Access