University thesis:
Dissertation, Georg-August-Universität Göttingen, 2023
Footnote:
Description:
The anaerobic bacterium Clostridioides difficile, renamed from Clostridium difficile, substantially accounts for nosocomial, antibiotic-associated infections worldwide. The complex dynamics of various traits shape the bacterial virulence, such as toxin production and gene sequence variants, multidrug resistances, and sporulation. C. difficile is also known for its mobile genome that comprises diverse mobile genetic elements (MGE), thereby enabling the spread of advantageous genes. The pathogen is extensively investigated to enlighten its virulence and dissemination. Strain isolation is main...