> Details
Heidegger, Simon
[Author];
Stritzke, Florian
[Author];
Dahl, Sarah
[Author];
Daßler-Plenker, Juliane
[Author];
Joachim, Laura
[Author];
Buschmann, Dominik
[Author];
Fan, Kaiji
[Author];
Sauer, Carolin M.
[Author];
Ludwig, Nils
[Author];
Winter, Christof
[Author];
Enssle, Stefan
[Author];
Li, Suqi
[Author];
Perl, Markus
[Author];
Görgens, André
[Author];
Haas, Tobias
[Author];
Orberg, Erik Thiele
[Author];
Göttert, Sascha
[Author];
Wölfel, Catherine
[Author];
Engleitner, Thomas
[Author];
Cortés-Ciriano, Isidro
[Author];
Rad, Roland
[Author];
Herr, Wolfgang
[Author];
Giebel, Bernd
[Author];
Ruland, Jürgen
[Author];
[...]
Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
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- Media type: E-Article
- Title: Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
- Contributor: Heidegger, Simon [VerfasserIn]; Stritzke, Florian [VerfasserIn]; Dahl, Sarah [VerfasserIn]; Daßler-Plenker, Juliane [VerfasserIn]; Joachim, Laura [VerfasserIn]; Buschmann, Dominik [VerfasserIn]; Fan, Kaiji [VerfasserIn]; Sauer, Carolin M. [VerfasserIn]; Ludwig, Nils [VerfasserIn]; Winter, Christof [VerfasserIn]; Enssle, Stefan [VerfasserIn]; Li, Suqi [VerfasserIn]; Perl, Markus [VerfasserIn]; Görgens, André [VerfasserIn]; Haas, Tobias [VerfasserIn]; Orberg, Erik Thiele [VerfasserIn]; Göttert, Sascha [VerfasserIn]; Wölfel, Catherine [VerfasserIn]; Engleitner, Thomas [VerfasserIn]; Cortés-Ciriano, Isidro [VerfasserIn]; Rad, Roland [VerfasserIn]; Herr, Wolfgang [VerfasserIn]; Giebel, Bernd [VerfasserIn]; Ruland, Jürgen [VerfasserIn]; Bassermann, Florian [VerfasserIn]; Coch, Christoph [VerfasserIn]; Hartmann, Gunther [VerfasserIn]; Poeck, Hendrik [VerfasserIn]
-
imprint:
19 September 2023
- Published in: Cell reports. Medicine ; 4(2023), 9 vom: Sept., Artikel-ID 101171, Seite 1-25
- Language: English
- DOI: 10.1016/j.xcrm.2023.101171
- ISSN: 2666-3791
- Identifier:
- Keywords: cancer immunotherapy ; cancer resistance ; extracellular vesicles ; innate immunity ; nucleic acid receptors ; personalized therapy ; RIG-I ; RNA ; STING
- Origination:
-
Footnote:
Online verfügbar: 31. August 2023, Artikelversion: 19. September 2023
- Description: Tumor-derived extracellular vesicles (EVs) have been associated with immune evasion and tumor progression. We show that the RNA-sensing receptor RIG-I within tumor cells governs biogenesis and immunomodulatory function of EVs. Cancer-intrinsic RIG-I activation releases EVs, which mediate dendritic cell maturation and T cell antitumor immunity, synergizing with immune checkpoint blockade. Intact RIG-I, autocrine interferon signaling, and the GTPase Rab27a in tumor cells are required for biogenesis of immunostimulatory EVs. Active intrinsic RIG-I signaling governs composition of the tumor EV RNA cargo including small non-coding stimulatory RNAs. High transcriptional activity of EV pathway genes and RIG-I in melanoma samples associate with prolonged patient survival and beneficial response to immunotherapy. EVs generated from human melanoma after RIG-I stimulation induce potent antigen-specific T cell responses. We thus define a molecular pathway that can be targeted in tumors to favorably alter EV immunomodulatory function. We propose “reprogramming” of tumor EVs as a personalized strategy for T cell-mediated cancer immunotherapy.
- Access State: Open Access