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Choudhary, Priyanka
[Author];
Monasso, Giulietta S.
[Author];
Karhunen, Ville
[Author];
Ronkainen, Justiina
[Author];
Mancano, Giulia
[Author];
Howe, Caitlin G.
[Author];
Niu, Zhongzheng
[Author];
Zeng, Xuehuo
[Author];
Guan, Weihua
[Author];
Dou, John
[Author];
Feinberg, Jason I.
[Author];
Mordaunt, Charles
[Author];
Pesce, Giancarlo
[Author];
Baïz, Nour
[Author];
Alfano, Rossella
[Author];
Martens, Dries S.
[Author];
Wang, Congrong
[Author];
Isaevska, Elena
[Author];
Keikkala, Elina
[Author];
Mustaniemi, Sanna
[Author];
Thio, Chris H. L.
[Author];
Fraszczyk, Eliza
[Author];
Tobi, Elmar W.
[Author];
Starling, Anne P.
[Author];
[...]
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence$article
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- Media type: E-Article
- Title: Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence$article
- Contributor: Choudhary, Priyanka [VerfasserIn]; Monasso, Giulietta S. [VerfasserIn]; Karhunen, Ville [VerfasserIn]; Ronkainen, Justiina [VerfasserIn]; Mancano, Giulia [VerfasserIn]; Howe, Caitlin G. [VerfasserIn]; Niu, Zhongzheng [VerfasserIn]; Zeng, Xuehuo [VerfasserIn]; Guan, Weihua [VerfasserIn]; Dou, John [VerfasserIn]; Feinberg, Jason I. [VerfasserIn]; Mordaunt, Charles [VerfasserIn]; Pesce, Giancarlo [VerfasserIn]; Baïz, Nour [VerfasserIn]; Alfano, Rossella [VerfasserIn]; Martens, Dries S. [VerfasserIn]; Wang, Congrong [VerfasserIn]; Isaevska, Elena [VerfasserIn]; Keikkala, Elina [VerfasserIn]; Mustaniemi, Sanna [VerfasserIn]; Thio, Chris H. L. [VerfasserIn]; Fraszczyk, Eliza [VerfasserIn]; Tobi, Elmar W. [VerfasserIn]; Starling, Anne P. [VerfasserIn]; Cosin-Tomas, Marta [VerfasserIn]; Urquiza, Jose [VerfasserIn]; Röder, Stefan [VerfasserIn]; Hoang, Thanh T. [VerfasserIn]; Page, Christian [VerfasserIn]; Jima, Dereje D. [VerfasserIn]; House, John S. [VerfasserIn]; Maguire, Rachel L. [VerfasserIn]; Ott, Raffael [VerfasserIn]; Pawlow, Xenia [VerfasserIn]; Sirignano, Lea [VerfasserIn]; Zillich, Lea [VerfasserIn]; Malmberg, Anni [VerfasserIn]; Rauschert, Sebastian [VerfasserIn]; Melton, Phillip [VerfasserIn]; Gong, Tong [VerfasserIn]; Karlsson, Robert [VerfasserIn]; Fore, Ruby [VerfasserIn]; Perng, Wei [VerfasserIn]; Laubach, Zachary M. [VerfasserIn]; Czamara, Darina [VerfasserIn]; Sharp, Gemma [VerfasserIn]; Breton, Carrie V. [VerfasserIn]; Schisterman, Enrique [VerfasserIn]; Yeung, Edwina [VerfasserIn]; Mumford, Sunni L. [VerfasserIn]; Fallin, M. Daniele [VerfasserIn]; LaSalle, Janine M. [VerfasserIn]; Schmidt, Rebecca J. [VerfasserIn]; Bakulski, Kelly M. [VerfasserIn]; Annesi-Maesano, Isabella [VerfasserIn]; Heude, Barbara [VerfasserIn]; Nawrot, Tim S. [VerfasserIn]; Plusquin, Michelle [VerfasserIn]; Ghantous, Akram [VerfasserIn]; Herceg, Zdenko [VerfasserIn]; Nisticò, Lorenza [VerfasserIn]; Vafeiadi, Marina [VerfasserIn]; Kogevinas, Manolis [VerfasserIn]; Vääräsmäki, Marja [VerfasserIn]; Kajantie, Eero [VerfasserIn]; Snieder, Harold [VerfasserIn]; Corpeleijn, Eva [VerfasserIn]; Steegers-Theunissen, Regine P. M. [VerfasserIn]; Yang, Ivana V. [VerfasserIn]; Dabelea, Dana [VerfasserIn]; Fossati, Serena [VerfasserIn]; Zenclussen, Ana C. [VerfasserIn]; Herberth, Gunda [VerfasserIn]; Magnus, Maria [VerfasserIn]; Håberg, Siri E. [VerfasserIn]; London, Stephanie J. [VerfasserIn]; Munthe-Kaas, Monica Cheng [VerfasserIn]; Murphy, Susan K. [VerfasserIn]; Hoyo, Cathrine [VerfasserIn]; Ziegler, Anette-G. [VerfasserIn]; Hummel, Sandra [VerfasserIn]; Witt, Stephanie [VerfasserIn]; Streit, Fabian [VerfasserIn]; Frank, Josef [VerfasserIn]; Räikkönen, Katri [VerfasserIn]; Lahti, Jari [VerfasserIn]; Huang, Rae-chi [VerfasserIn]; Almqvist, Catarina [VerfasserIn]; Hivert, Marie-France [VerfasserIn]; Jaddoe, Vincent W. V. [VerfasserIn]; Järvelin, Marjo-Riitta [VerfasserIn]; Kantomaa, Marko [VerfasserIn]; Felix, Janine F. [VerfasserIn]; Sebert, Sylvain [VerfasserIn]
- imprint: 05 December 2023
- Published in: Molecular psychiatry ; (2023), Seite 1-11
- Language: English
- DOI: 10.1038/s41380-023-02331-5
- ISSN: 1476-5578
- Identifier:
- Keywords: Genetics ; Predictive markers
- Origination:
- Footnote:
- Description: Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
- Access State: Open Access