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Gatzemeier, Luisa Maria [Author] ; Meyer, Franc [Degree supervisor]; Outeiro, Tiago [Degree supervisor]

Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation

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  • Media type: E-Book; Thesis
  • Title: Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation
  • Contributor: Gatzemeier, Luisa Maria [Author]; Meyer, Franc [Degree supervisor]; Outeiro, Tiago [Degree supervisor]
  • Published: Göttingen, 2024
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: Alpha-Synuclein ; Parkinson's Disease ; Chemical Protein Synthesis ; Solid-Phase Peptide Synthesis ; Native Chemical Ligation ; Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2024
  • Footnote:
  • Description: Parts of this chapter have already been published and have been adapted from the original publication: L. M. Gatzemeier, F. Meyer, U. Diederichsen, T. F. Outeiro, Chemical Synthesis of Alpha-Synuclein Proteins via Solid-Phase Peptide Synthesis and Native Chemical Ligation, Chem. Eur. J. 2023, 29, e202300649, doi: 10.1002/chem.202300649.[1] α-Synuclein (α-Syn) is a 140-amino acid (AA) protein implicated in neurodegenerative disorders known as synucleinopathies, such as Parkinson’s disease (PD), where it accumulates in proteinaceous inclusions in the brain. In neuronal cells, α-Syn is thought...
  • Access State: Open Access
  • Rights information: Attribution (CC BY)