> Details
Delacher, Michael
[Author];
Schmidleithner, Lisa Maria
[Author];
Simon, Malte
[Author];
Stüve, Philipp Florenz
[Author];
Sanderink, Lieke
[Author];
Hotz-Wagenblatt, Agnes
[Author];
Wuttke, Marina
[Author];
Schambeck, Kathrin
[Author];
Ruhland, Brigitte
[Author];
Hofmann, Veronika
[Author];
Bittner, Sebastian
[Author];
Ritter, Uwe
[Author];
Pant, Asmita
[Author];
Helbich, Sara Salome
[Author];
Voss, Morten
[Author];
Lemmermann, Niels Arne Wilhelm
[Author];
Bessiri-Schake, Lisa
[Author];
Bohn, Toszka
[Author];
Eigenberger, Andreas
[Author];
Menevse, Ayse Nur
[Author];
Gebhard, Claudia
[Author];
Strieder, Nicholas
[Author];
Abken, Hinrich
[Author];
Rehli, Michael
[Author];
[...]
The effector program of human CD8 T cells supports tissue remodeling
Sharing
Reference
management
Direct link
Bookmarks
Remove from
bookmarks
Share this by email
Share this on Twitter
Share this on Facebook
Share this on Whatsapp
- Media type: E-Article
- Title: The effector program of human CD8 T cells supports tissue remodeling
- Contributor: Delacher, Michael [VerfasserIn]; Schmidleithner, Lisa Maria [VerfasserIn]; Simon, Malte [VerfasserIn]; Stüve, Philipp Florenz [VerfasserIn]; Sanderink, Lieke [VerfasserIn]; Hotz-Wagenblatt, Agnes [VerfasserIn]; Wuttke, Marina [VerfasserIn]; Schambeck, Kathrin [VerfasserIn]; Ruhland, Brigitte [VerfasserIn]; Hofmann, Veronika [VerfasserIn]; Bittner, Sebastian [VerfasserIn]; Ritter, Uwe [VerfasserIn]; Pant, Asmita [VerfasserIn]; Helbich, Sara Salome [VerfasserIn]; Voss, Morten [VerfasserIn]; Lemmermann, Niels Arne Wilhelm [VerfasserIn]; Bessiri-Schake, Lisa [VerfasserIn]; Bohn, Toszka [VerfasserIn]; Eigenberger, Andreas [VerfasserIn]; Menevse, Ayse Nur [VerfasserIn]; Gebhard, Claudia [VerfasserIn]; Strieder, Nicholas [VerfasserIn]; Abken, Hinrich [VerfasserIn]; Rehli, Michael [VerfasserIn]; Hühn, Jochen [VerfasserIn]; Beckhove, Philipp [VerfasserIn]; Hehlgans, Thomas [VerfasserIn]; Junger, Henrik Horst Gerhard [VerfasserIn]; Geissler, Edward K. [VerfasserIn]; Prantl, Lukas [VerfasserIn]; Werner, Jens-Martin [VerfasserIn]; Schmidl, Christian [VerfasserIn]; Brors, Benedikt [VerfasserIn]; Imbusch, Charles [VerfasserIn]; Feuerer, Markus [VerfasserIn]
- imprint: January 16 2024
- Published in: Journal of experimental medicine ; 221(2024), 2, Artikel-ID e20230488, Seite 1-22
- Language: English
- DOI: 10.1084/jem.20230488
- ISSN: 1540-9538
- Identifier:
- Origination:
- Footnote:
- Description: CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling. Activated CD8 T cells could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial cells for enhanced regeneration potential. Blocking the EGFR or the effector cytokines IFN-γ and TNF could inhibit tissue remodeling. This regenerative program enhanced tumor spheroid and stem cell-mediated organoid growth. Using single-cell gene expression analysis, we identified an AREG+, tissue-resident CD8 T cell population in skin and adipose tissue from patients undergoing abdominal wall or abdominoplasty surgery. These tissue-resident CD8 T cells showed a strong TCR clonal relation to blood PD1+TIGIT+ CD8 T cells with tissue remodeling abilities. These findings may help to understand the complex CD8 biology in tumors and could become relevant for the design of therapeutic T cell products.
- Access State: Open Access