University thesis:
Dissertation, Georg-August-Universität Göttingen, 2024
Footnote:
Description:
Cross-coupling chemistry stands out as a fundamental tool in synthetic organic chemistry for forging C‒C and C‒Het bonds. However, the necessity for substrate prefunctionalization imposes significant sustainability challenges on these transformations. In contrast, advancements in transition metal-catalyzed direct functionalization of ubiquitous C‒H bonds present a more sustainable avenue for constructing complex molecular structures. Despite the pivotal contributions of C–H activation, also driven by key principles like atom- and step-economy, this approach has inherent limitations. To over...