University thesis:
Dissertation, Universität Rostock, 2021 (Kumulative Dissertation)
Footnote:
Enthält Zeitschriftenbeiträge
GutachterInnen: Jochen Klaus Schubert (Universitätsmedizin Rostock, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie), Dagmar-Christiane Fischer (Universitätsmedizin Rostock, Klinik und Poliklinik Kinder- und Jugendmedizin), Christopher Anthony Mayhew (Leopold-Franzens-Universität Innsbruck, Institut für Atemgasanalytik)
Zeitschriftennachweis: 1) Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry. Pugliese Giovanni, Piel Felix, Trefz Phillip, Sulzer Philipp, Schubert Jochen Klaus, Miekisch Wolfram. Analytical Bioanalytical Chemistry 2020; 412, 7131–7140. ISSN:1618-2650. DOI: https://doi.org/10.1007/s00216-020-02846-8. 2) Extending PTR based breath analysis to real-time monitoring of reactive volatile organic compounds. Pugliese Giovanni, Trefz Phillip, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Analyst 2019; 144, 7359–7367. ISSN: 1364-5528. DOI: https://doi.org/10.1039/C9AN01478K. 3) Effects of elevated oxygen levels on VOC analysis by means of PTR-ToF-MS. Trefz Phillip, Pugliese Giovanni, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Journal of Breath Research 2019; 13(4):046004. ISSN: 1752-7163. DOI: 10.1088/1752-7163/ab28ec
Description:
We improved the measurement capabilities of PTR-MS for real-time monitoring of breath VOCs in the clinical environment. In the first study, we evaluated the effects of a modular ion-funnel onto PTR-MS performances in terms of sensitivity and LODs. In the second study we optimized instrumental conditions for direct breath-resolved real-time monitoring of highly reactive compounds. In the third study, we evaluated the effects of potential confounders from the clinical environment such as elevated inspired O2 concentrations onto PTR-MS based VOC analysis.<eng>