University thesis:
Dissertation, Georg-August-Universität Göttingen, 2024 (Kumulative Dissertation)
Footnote:
Description:
A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal conduction, local calcium handling, and atrial excitation-contraction coupling, and therefore presents an attractive therapeutic target. In neurons, CaV1.3 is a crucial regulator controlling postsynaptic signal transmission. Despite the longstanding investigation of its electrophysiology and regulatory interactions, the molecular mechanisms behind CaV1.3 channel clustering in...