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Schwenzer, Niko [Author] ; Vogl, Christian [Degree supervisor]; Lehnart, Stephan [Degree supervisor]; Rizzoli, Silvio [Degree supervisor]

Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells

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  • Media type: E-Book; Thesis
  • Title: Nanoscale organization of CaV1.3 L-type Ca2+ channel clusters in electrically excitable cells
  • Contributor: Schwenzer, Niko [Author]; Vogl, Christian [Degree supervisor]; Lehnart, Stephan [Degree supervisor]; Rizzoli, Silvio [Degree supervisor]
  • Published: Göttingen, 2024
  • Extent: 1 Online-Ressource; Illustrationen, Diagramme
  • Language: English
  • Identifier:
  • Keywords: CaV1.3 ; calcium channel clusters ; cluster size ; atrial cardiomyocytes ; hipsc-cm ; super-resolution ; STED ; LTCC clustering ; DNA-PAINT ; single particle tracking ; thesis ; Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Georg-August-Universität Göttingen, 2024 (Kumulative Dissertation)
  • Footnote:
  • Description: A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3, which translates electrical signals into a cellular response. In the heart, CaV1.3 holds a central role in pacemaking, signal conduction, local calcium handling, and atrial excitation-contraction coupling, and therefore presents an attractive therapeutic target. In neurons, CaV1.3 is a crucial regulator controlling postsynaptic signal transmission. Despite the longstanding investigation of its electrophysiology and regulatory interactions, the molecular mechanisms behind CaV1.3 channel clustering in...
  • Access State: Open Access