University thesis:
Dissertation, Georg-August-Universität Göttingen, 2024
Footnote:
Description:
ALS is a rapidly progressing neurodegenerative disease characterized by motor neuron death ultimately leading to paralysis and respiratory failure. While a great deal of progress has been made deciphering the underlying pathogenic pathways, no curative therapy is available today. Over the last few decades, alterations in energy homeostasis and glucose metabolism have emerged as common features across many different forms of ALS. Disturbed energy homeostasis and a general hypermetabolism are observed in ALS patients even before motor symptoms begin, suggesting it to be an early and possibly ...