University thesis:
Dissertation, Georg-August-Universität Göttingen, 2024
Footnote:
Description:
3D imaging of the immune cell status in a complex tumour volume represents an important step towards understanding the anti-tumour immune response and a decisive predictor of the efficacy of immune checkpoint inhibition. The gold standard for this issue is histology. However, due to the limitation of the sample size and the random selection of a small tumour area, this only allows an imprecise statement to be made about the 3D distribution of immune cells in a larger volume. A promising alternative here is light sheet microscopy, which allows both tomographic fluorescence images to be taken...