University thesis:
Dissertation, Georg-August-Universität Göttingen, 2024
Footnote:
Description:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by great molecular heterogeneity, with a large number of epigenetic factors playing a central role in addition to known genetic changes such as the KRAS mutation. Due to the high diversity, an individualized therapy adapted to the genotype and phenotype appears to offer a promising opportunity. The aim of this study was to understand the tumour biological consequences and therapeutic vulnerabilities of pancreatic cancer subtypes characterized by a loss of expression of ARID1A (AT-rich interactive domain-containing protein 1A). ARID1A ...