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Monecke, Sebastian [Author] ; Dressel, Ralf [Degree supervisor]; Dressel, Ralf [Other]; Wienands, Jürgen [Other]; Mansouri, Ahmed [Other]; Paulus, Walter [Other]

Immunogenicity of pluripotent stem cells and their differentiation products

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  • Media type: E-Book; Thesis
  • Title: Immunogenicity of pluripotent stem cells and their differentiation products
  • Contributor: Monecke, Sebastian [Author]; Dressel, Ralf [Betreuer]; Wienands, Jürgen [Gutachter]; Mansouri, Ahmed [Gutachter]; Paulus, Walter [Gutachter]
  • imprint: 2012
  • Extent: Online-Ressource (PDF-Datei: 4,9 MB)
  • Language: English
  • Identifier:
  • Keywords: Hochschulschrift
  • Origination:
  • University thesis: Göttingen, Univ., Diss., 2013
  • Footnote:
  • Description: Embryonic stem cells (ESCs) hold great promises for regenerative medicine since they are able to differentiate into any cell type of an adult body. However, transplantation of these cells is associated with at least two severe risks: the risk of tumor formation in the recipient and the risk of an immune rejection. Since ESCs have to be transplanted in an allogeneic setting, major histocompatibility complex (MHC) mismatch could lead to rapid immune rejection of these cells. Recently, the usage of autologous pluripotent stem cells for transplantation became conceivable by description of induc...
  • Access State: Open Access