Description:
Rett Syndrome (RS) is a neurodevelopmental disorder caused primarily by mutations in a Mecp2 gene on the X chromosome that encodes methyl-cytosine binding protein (MeCP2). MeCP2 acts as a transcriptional repressor and an activator for a number of genes such as DLX5/ Dlx5 and Bdnf. One of the effects of diminished Mecp2 expression activity is the appearance of a Rett-like phenotype including tremors, severe breathing irregularities, and hypoactivity. Neurons of pre-Bötzinger complex (preBötC), the most important component of the complex respiratory network on which the generation of respirat...