Schremmer, Carmen
[Author]
;
Schäfer, Katrin
[Degree supervisor];
Schäfer, Katrin
[Other];
Patschan, Daniel
[Other]
Bedeutung von Urokinase-Plasminogen-Aktivator für das Wachstum und die Stabilität arteriosklerotischer Gefäßläsionen im Apolipoprotein-E-Knockout-Mausmodell
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Media type:
E-Book;
Thesis
Title:
Bedeutung von Urokinase-Plasminogen-Aktivator für das Wachstum und die Stabilität arteriosklerotischer Gefäßläsionen im Apolipoprotein-E-Knockout-Mausmodell
Other titles:
Nebentitel: Lack of urokinase plasminogen activator promotes progression and instability of atherosclerotic lesions on apolipoprotein E-knockout mice
Description:
Urokinase plasminogen activator (uPA) is strongly expressed in atherosclerotic lesions, but the overall effect of the protease on plaque composition and growth remains controversial. In the present study, apolipoprotein E-deficient (apoE-/-) mice were intercrossed with mice which were lacking the uPA gene (doubleknockout; DKO). In ferric chloride-induced carotid artery lesions in chow-fed mice, uPA deficiency increased neointimal size (P=0.015) and luminal stenosis (P=0.014), while reducing media thickness (P=0.002). A lack of uPA also increased the size of and the luminal obstruction from ...