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Guli, Xiati [Author]

Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path

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  • Media type: E-Book; Thesis
  • Title: Role of HCN channels in regulation of synaptic plasticity at early postnatal medial perforant path
  • Contributor: Guli, Xiati [Author]
  • imprint: 2013
  • Extent: Online-Ressource; Ill., graph. Darst
  • Language: English
  • Identifier:
  • Keywords: Neuronale Plastizität > HCN-Kanal
  • Origination:
  • University thesis: Rostock, Univ., Med. Fak., Diss., 2013
  • Footnote:
  • Description: HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.
  • Access State: Open Access