Die Bedeutung der Thymidinphosphorylase bei Patienten mit lokal fortgeschrittenem Rektumkarzinom (UICC-Stadium-II/-III) im Kontext einer 5-FU basierten multimodalen Therapie
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Media type:
E-Book;
Thesis
Title:
Die Bedeutung der Thymidinphosphorylase bei Patienten mit lokal fortgeschrittenem Rektumkarzinom (UICC-Stadium-II/-III) im Kontext einer 5-FU basierten multimodalen Therapie
:
eien immunhistochemische, patientenorientierte Studie mit Langzeit-Follow-Up
Other titles:
Nebentitel: The significance thymidine phosphorylase has on patients with locally advanced rectal cancer (UICC-Stadium-II/-III) with regard to a 5-FU based multimodal therapy
Description:
Thymidine phosphorylase (TP) is an enzyme, which is involved in the physiological metabolism of each cell. There it acts as an angiogenic factor, but further catalyzes at least three known reactions, which are related to the 5-Fluorouracil (5-FU) metabolism. Previous studies revealed that carcinoma cells, compared with normal tissue, contain an increased expression of TP. For this reason, the present study, immunohistochemically examined the tissue of 223 patients with locally advanced rectal cancer for expression of TP. All patients were subject to multimodal therapy regimens under standar...