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Media type:
E-Book;
Thesis
Title:
Zytokinabhängige Expression von EGF und VEGF und ihrer Rezeptoren EGFR und VEGFR-1 im Tumormikromilieu des kolorektalen Karzinoms
Other titles:
Nebentitel: Cytokine-dependent gene expression of EGF, VEGF and their receptors EGFR and VEGFR-1 in the microenvironment of colorectal carcinoma
Description:
Several diseases associated with chronic inflammation - for example gastro-esophageal reflux, Helicobacter pylori infection and chronic (gastro)enteritis in the context of inflammatory bowel disease (IBD) - promote tumor formation and growth. Secretion of cytokines such as TNF-α, IL-1β and IFN-γ, and of growth factors such as epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) by tumor cells or surrounding inflammatory cells causes development of a tumor growth-promoting microenvironment. This work was to investigate gene expression of the growth factors EGF and VEGF...