Fledrich, Robert
[Author]
;
Sereda, Michael
[Degree supervisor];
Sereda, Michael
[Other];
Nave, Klaus-Armin
[Other];
Göpfert, Martin
[Other];
Martini, Rudolf
[Other]
Der Einfluss von Neuregulin-1 auf Erkrankungen des peripheren Nervensystems
Description:
A duplication of the gene encoding the peripheral myelin protein 22kDa (PMP22) underlies the commonest inherited neuropathy, Charcot Marie Tooth disease 1A (CMT1A). Although demyelination is a characteristic disease feature, the clinical impairment of CMT1A patients is determined by the extent of axonal loss. Patients suffer from slowly progressive, distally pronounced muscle atrophy and sensory impairments. A therapy is not available yet. In the present doctoral thesis it is shown that, with the help of Pmp22 transgenic rodent models for CMT1A, Pmp22 overexpressing Schwann cells acquire a ...