Hiller, Henrik
[Author]
;
Gross, Oliver
[Degree supervisor];
Gross, Oliver
[Other];
Krick, Wolfgang
[Other];
Oppermann, Martin
[Other]
Neue Therapieansätze für das Alport-Syndrom: Nephroprotektives, antifibrotisches und antiinflammatorisches Potential von Paricalcitol additiv zu Ramipril in einem Mausmodell für progressive Nierenfibrose
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Thesis
Title:
Neue Therapieansätze für das Alport-Syndrom: Nephroprotektives, antifibrotisches und antiinflammatorisches Potential von Paricalcitol additiv zu Ramipril in einem Mausmodell für progressive Nierenfibrose
Other titles:
New therapeutic approaches for the Alport syndromes disease: nephroprotective, antifibrotic and antiinflammatory effects of Paricalcitol on top of Ramipril in a mouse model for progressie renal fibrosis
Description:
Background: Alport syndrome (AS) is a hereditary, progressive, glomerular nephritis that leads to end-stage renal disease in young adult life. AS is a rare and presently uncurable condition; available treatments tackle symptoms only. Considering the high burden of the disease on individuals, their families and society, establishing new therapies is a pressing need. Aims: this study aimed to estimate the nephroprotective effect of Paricalcitol alone and in combination with Ramipril on COL4A3-knockout mice. Methods: The COL4A3-knockout mouse which develops a progressive glomerulonephritis sim...