Description:
In Escherichia coli and other enterobacteria, the homologous small RNAs (sRNAs) GlmY and GlmZ act in a hierarchical manner to feedback control expression of key enzyme glucosamine-6-phosphate (GlcN6P) synthase GlmS. Enzyme GlmS catalyzes formation of GlcN6P, which is the rate limiting reaction in the pathway of cell wall biosynthesis. Only sRNA GlmZ can activate the glmS mRNA by base-pairing, which releases the ribosomal binding site and allows synthesis of GlmS. The second sRNA GlmY acts indirectly to activate glmS by stabilizing GlmZ in a process that involves protein YhbJ. However, the m...