Tolö, Johan
[Author]
;
Kügler, Sebastian
[Degree supervisor];
Kügler, Sebastian
[Other];
Mironov, Sergej
[Other];
Moser, Tobias
[Other]
Effects of [alpha]/[beta]/[gamma]-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
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Media type:
E-Book;
Thesis
Title:
Effects of [alpha]/[beta]/[gamma]-Synuclein overexpression on the mitochondria and viability of neurons, examined using genetically encoded fluorescent sensors
Description:
Parkinson's disease (PD) is the second most common neurodegenerative disease and it affects more than 1% of the worlds population over the age of 65. A hallmark of PD is the appearance of Lewy bodies (LBs) throughout the brain and a major component of these intracellular inclusions is the small soluble protein α-Synuclein (αS). Rare familial mutations as well as duplications and triplications of the gene coding for αS leads to early onset PD and this makes a role for αS in the etiology of PD likely but exactly how αS contributes to the disease is still unknown. No genetic link to PD has so ...