Description:
The establishment of a permissive tumor microenvironment is a key step for tumor progression and metastasis formation. Tumor cells are known for their ability to create such a favorable tumor niche by influencing the surrounding benign stroma cells through the secretion of cytokines or growth factors. Recently, there is increasing evidence that also extracellular vesicles (EV) released by the tumor cells are important means of intercellular communication. Therefore, we aimed to investigate their role in tumor-tumor and tumor-stroma crosstalk in human breast cancer. Human breast cancer cells...