Description:
Hundreds of databases offer vast amounts of literature knowledge about biological signaling networks. However, this knowledge is rarely integrated into current bioinformatic analyzes due to challenges in the programmatic access and transformation of this data. This thesis focuses on the integration of prior knowledge into methods for network reconstruction. The motivation is to improve the performance of bioinformatic algorithms and methods by facilitating the integration of available pathway data as prior knowledge. First, the fundamentals of biological networks and pathways, their encodin...