5-Fluorouracil-Spiegelbestimmung unter neoadjuvanter Radiochemotherapie und adjuvanter Chemotherapie beim lokal fortgeschrittenen Rektumkarzinom
: Analyse der pharmakologischen Varibilität von 5-Fluorouracil mittels Nanopartikelimmunoassays
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Media type:
E-Book;
Thesis
Title:
5-Fluorouracil-Spiegelbestimmung unter neoadjuvanter Radiochemotherapie und adjuvanter Chemotherapie beim lokal fortgeschrittenen Rektumkarzinom
:
Analyse der pharmakologischen Varibilität von 5-Fluorouracil mittels Nanopartikelimmunoassays
Other titles:
Nebentitel: Effects of a body surface area based 5-fluoruracil dosing under the neoadjuvant radiochemotherapy and adjuvant chemotherapy in locally advanced rectal cancer
Description:
5-fluoruracil (5-FU) still remains the backbone of chemotherapy in colorectal cancer and effects as a radiosensitizer for radiotherapy. During the last decades several clinical trials have demonstrated that neoadjuvant 5-FU based chemoradiotherapy (CRT) significantly improves locoregional control of rectal cancer. The standard administration based on body surface area (bsa) results in highly variable drug plasma levels. With the Saladax immunoassay My5FU® a test was established to determine inter- and intraindividual dose variations. 5-FU plasma levels were correlated with early response pa...