Description:
The estrogen receptor-α (ERα) acts as a nuclear transcription factor to promote estrogen-induced transcription and plays a central role in the progression of ER-positive tumors. ERα binds to the consensus DNA elements referred to as Estrogen Response Elements (EREs) which act as enhancers mostly occupying distal regions. In our study, we show that Bromodomain-containing protein, BRD4 depletion/inhibition regulates estrogen-induced transcription by affecting RNA polymerase II (RNAPII) and histone monoubiquitination in ER-positive MCF7 cells. Furthermore, BRD4 controls the proliferation of br...