Diederich, Christine
[Author]
;
Focke, Niels
[Degree supervisor];
Focke, Niels
[Other];
Paulus, Walter
[Other];
Dechent, Peter
[Other]
Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms
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Thesis
Title:
Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms
Other titles:
Nebentitel: Investigation of structural cerebral alterations in patients with idiopathic-generalized epilepsy with special emphasis on the Janz syndrome
Description:
The aim of this doctoral thesis was to investigate (micro-) structural alterations of the brain in patients with idiopathic-generalized epilepsy. 25 patients, subdivided in IGE (13) and in the subclass juvenile myoclonic epilepsy (JME, 12), as well as 44 healthy controls were scanned at a 3T MRI-Scanner at the MR Research Group Göttingen with conventional and new MRI-protocols (T1-weighted images, DTI, T1 Relaxometry and semi-quantitative magnetization transfer mapping). Using TBSS for the DTI data, a comparison between patients and healthy controls shows large changes in white matter tract...