Description:
Neuregulin (NRG) 1 contains an epidermal growth factor (EGF)-like signaling domain and serves as a ligand for receptor tyrosine kinases of the ErbB family. ErbB4, the main neuronal NRG1 receptor in the brain, is enriched in GABAergic interneurons. NRG1/ErbB4 signaling regulates different aspects of nervous system development and synaptic plasticity in the mature brain. Variants of the human NRG1 and ERBB4 genes are genetic risk factors for schizophrenia, and inhibitory network dysfunctions have been implicated in schizophrenia. For NRG1 most of the at-risk haplotypes are located in non-codi...