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Schade, Anna [Author] ; Steinhoff, Gustav [Other]; Pützer, Brigitte Maria [Other]; Brunner, Stefan [Other] Universität Rostock, Universitätsmedizin Rostock

MicroRNA-based stem cell modifications using magnetic transfection complexes

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  • Media type: E-Book; Thesis
  • Title: MicroRNA-based stem cell modifications using magnetic transfection complexes : a non-viral approach towards cardiac regeneration
  • Parallel title: MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe : ein nicht-viraler Ansatz für die kardiale Regeneration
    MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe
  • Contributor: Schade, Anna [Author]; Steinhoff, Gustav [Other]; Pützer, Brigitte Maria [Other]; Brunner, Stefan [Other]
  • Corporation: Universität Rostock ; Universitätsmedizin Rostock
  • Published: Rostock: Universität, 2015
  • Extent: 1 Online-Ressource
  • Language: English
  • Identifier:
  • Keywords: Hochschulschrift
  • Origination:
  • University thesis: Dissertation, Universität Rostock, 2015
  • Footnote:
  • Description: Regenerative properties of human mesenchymal stem cells (hMSC) can be enhanced by genetic modifications. Thus we aimed to develop a magnetic non-viral vector for microRNA (miR) delivery in freshly isolated hMSCs. miR/PEI/MNP transfection showed a better long term performance compared to miR/PEI transfection. Moreover magnetically modified hMSCs could be guided by an external magnet contributing to enhanced cell engraftment. Conclusively a magnetic non-viral carrier for efficient miR delivery in freshly isolated hMSCs was developed allowing specific control of stem cells and magnetic targeting.<eng>
  • Access State: Open Access