Description:
As no successful therapeutic approach to treat Alzheimer’s disease (AD) has been developed to date, preventative strategies and non-pharmacological interventions increasingly become a major research focus. In recent years, substantial evidence for a protective role of physical and cognitive activity on the risk of AD has been growing. In the present study, the effect of a challenging environment in combination with regular exercise on the Alzheimer-like pathology of the Tg4-42 and 5XFAD mouse models was investigated. The Tg4-42 model overexpresses N-truncated Aβ4-42 without any mutations an...