University thesis:
Dissertation, Georg-August-Universität Göttingen, 2016
Footnote:
Description:
The active contribution of oligodendrocytes and astrocytes to sustain brain physiology was completely underestimated, but severe consequences of their dysfunction in various diseases and glia-specific mutants emphasized their importance in maintaining neuronal integrity and function. By the intimate interconnection between neurons, oligodendrocytes and astrocytes a network is established allowing bidirectional interaction. Improved techniques to analyze brain energy metabolism revealed that a high amount of glucose is not oxidatively metabolized. Thus, lactate, the end-product of aerobic gl...