University thesis:
Dissertation, Georg-August-Universität Göttingen, 2016
Footnote:
Description:
In this work, the properties of ion channels in biological membranes are characterized. Two systems are investigated: The conductance changes of the membrane of the axon initial segment (AIS) due to fast sodium channels, and the recently discovered light sensitive ion channel Chronos. The latter investigation focused purely on the properties of the light gated channels and not, for example, their distribution in the membrane. As vectors holding the Chronos gene can be inserted into simple, small, round cells such as HEK cells, the electrophysiological measurements can be performed with stan...