University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and shows characteristics of skeletal muscle differentiation. RMS occur in two main histological subtypes in children: alveolar RMS (ARMS) and embryonal RMS (ERMS), which are associated with distinct genetic and molecular alterations. Despite more intensive therapies during the last decades, patients with metastatic RMS have a very poor prognosis. Thus, it is of uttermost importance to increase the knowledge of the basic biology of RMS and to develop new treatment strategies in order to improve the outcome of ...