University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Post-translational modifications serve as a cellular mechanism for the regulation of the activity, stability and localization of proteins. SUMOylation is a dynamic and reversible post-translational modification, which entails the attachment of a SUMO protein to a lysine residue of the target protein. SUMOylation is involved in the regulation of numerous cellular processes including transcription, nucleocytoplasmic trafficking, and DNA repair. Three or four SUMO paralogs are present in mammals – SUMO1, SUMO2, SUMO3 and SUMO4. SUMO2 and SUMO3 exhibit extremely high sequence homology and there...