University thesis:
Dissertation, Georg-August-Universität Göttingen, 2017
Footnote:
Description:
Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept studies, mostly in rodent models, have shown promising results. Nevertheless, to be therapeutically relevant it is essential to test evolving therapeutic strategies in large animal models with high predictive value as to clinical outcome. Unfortunately, a lack of pluripotent stem cell models available in most animal species used for late stage preclinical testing creates a majo...