University thesis:
Dissertation, Georg-August-Universität Göttingen, 2016
Footnote:
Description:
Aneuploidy and increased cell migration and invasion are hallmarks of aggressive human cancers. Aneuploidy derives from an increased rate of perpetual chromosome missegregation during mitosis, referred to as chromosomal instability (CIN). CIN contributes to the development of genetic heterogeneity and is thought to support rapid adaptation of cancer cells. Significantly, late tumor stages, which exhibit metastasis, are not only characterized by increased cancer cell migration and invasion, but also by high levels of CIN, both of which correlate with poor patient prognosis. Therefore, I aime...